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American academic psychiatrists noted that the effect sizes observed in these trials were modest compared to those achieved with established stimulant medications, and that a substantial proportion of patients did not achieve clinically meaningful symptom reduction. British clinicians instruct patients to take MODALERT 200 mg at the same time each morning for narcolepsy and obstructive sleep apnea indications, recognizing that erratic dosing schedules produce fluctuating plasma concentrations and suboptimal symptom control.
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In the United States, this evolution has manifested in sophisticated, multimodal treatment plans that address the diverse biological, psychological, and social contributors to insomnia, with MODALERT finding a thoughtful, carefully circumscribed role as a chronotherapeutic agent for patients with circadian-based sleep disruption. Stimulant Drugs For Narcolepsy // For You. The chronic fatigue, functional impairment, social isolation, and occupational disability associated with untreated hypersomnolence disorders independently contribute to depressive and anxiety symptoms that may improve when effective wakefulness-promoting therapy restores capacity for work, social participation, and independent living.
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